Big 🐓 Brock vs Eugene Cyril Smith III

Week 15 TNF gives us an NFC West showdown between the San Francisco 49ers (9-4) and Seattle Seahawks (7-6) at Lumen Field. Can the rookie Brock Purdy continue his dominance and make it 3 wins in a row? 👑

We should see another exciting TNF game after Baker Mayfield's stunning, last-second victory over the Raiders in Week 14. This matchup represents a clash of styles. San Francisco primarily relies on the strength of its defense, while Seattle tends to find itself in higher-scoring, back-and-forth shootouts. However, Thursday Night Football games have a tendency to be lower scoring, so let’s dig into the latest odds and pick out our San Francisco vs Seattle best bets for this Week 15 TNF matchup.

In the first meeting between these two teams, a 27-7 San Francisco victory back in Week 2, the Niners were able to smother Seattle’s offense. The Seahawks amassed just 216 total yards, most of which came through the air. Geno Smith could once again be asked to do a lot of the heavy lifting here.

Niners coach Kyle Shanahan should be able to put his young quarterback in a position to succeed by leaning heavily on the run game with Christian McCaffrey and then giving him easy throws by using play action.

Seattle has allowed 20-plus points in five straight games, and this San Francisco offense has too much talent to be shut down by an average (at best) defense.

• The 49ers are 8-5 against the spread, while the Seahawks have a 6-7 ATS record.

• The Under is 7-6 in San Francisco’s games and 5-8 in Seattle’s games so far this year.

• The 49ers are 1-3 straight up as road favorites this season.